{"created":"2023-12-19T04:59:57.930651+00:00","id":2000050,"links":{},"metadata":{"_buckets":{"deposit":"a2c34dcb-7e0a-4466-bee1-721ff395c837"},"_deposit":{"created_by":18,"id":"2000050","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000050"},"status":"published"},"_oai":{"id":"oai:hokuriku.repo.nii.ac.jp:02000050","sets":["29","29:1695351854159"]},"author_link":[],"control_number":"2000050","item_10002_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Nifedipine soft capsules show biphasic softening because of the humidity","subitem_alternative_title_language":"en"}]},"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-09-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"55","bibliographicPageEnd":"48","bibliographicPageStart":"39","bibliographic_titles":[{"bibliographic_title":"北陸大学紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Bulletin of Hokuriku University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は以前にソフトカプセル硬度の変化が湿度によって引き起こされることを示している。\n本研究では、以前の報告とは一部方法を変更した上で硬さの測定を実施し、湿度によりニフェジピンソフトカプセルの軟化が二相性に起こることを示す。高湿度でカプセルが軟化する時には、1、ないし2 日くらいで急激に起こるが、それに伴い起こる重量変化は急激には起こらない。つまり、湿度、あるいは水分は確かにカプセル軟化の要因である。ただ、湿度という指標とカプセル軟化はパラレルではなく、水分活性がその硬さと非常に良い負の相関を示す。ソフトカプセルの製造において乾燥過程があるので、ソフトカプセル自体が吸水することが不思議ではないが、ニフェジピンソフトカプセルの軟化は水分の吸収により変形するほどに極端に起こる。トコフェロールソフトカプセルもまた二相性の軟化を示すが、その軟化の様式はニフェジピンソフトカプセル軟化の様式とは異なるようである。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_full_name_3":{"attribute_name":"著者（英）","attribute_value_mlt":[{"affiliations":[{"affiliationNames":[{"affiliationName":"Faculty of Pharmaceutical Sciences, Hokuriku University","affiliationNameLang":"en"}]}],"names":[{"name":"Sekimoto Keiko","nameLang":"en"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"Faculty of Pharmaceutical Sciences, Hokuriku University","affiliationNameLang":"en"}]}],"names":[{"name":"komatsu Yuka","nameLang":"en"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"Faculty of Pharmaceutical Sciences, Hokuriku University","affiliationNameLang":"en"}]}],"names":[{"name":"Takano Katsuhiko","nameLang":"en"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"Amall incorporated","affiliationNameLang":"en"}]}],"names":[{"name":"Nakagawa Teruaki","nameLang":"en"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"北陸大学","subitem_publisher_language":"ja"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2186-3989","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"北陸大学薬学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"関本啓好","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"50293303","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50293303"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"北陸大学薬学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小松優花","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"北陸大学薬学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"高野克彦","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"50293303","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50293303"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"㈱アモール","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中川輝昭","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-19"}],"filename":"yaku03.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://hokuriku.repo.nii.ac.jp/record/2000050/files/yaku03.pdf"},"version_id":"c1781091-0f97-43d0-a154-6cc5462df429"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ソフトカプセルの硬さ","subitem_subject_language":"ja"},{"subitem_subject":"水分活性","subitem_subject_language":"ja"},{"subitem_subject":"湿度","subitem_subject_language":"ja"},{"subitem_subject":"デュロメータ","subitem_subject_language":"ja"},{"subitem_subject":"軟化","subitem_subject_language":"ja"},{"subitem_subject":"toughness of soft capsules","subitem_subject_language":"en"},{"subitem_subject":"water activity","subitem_subject_language":"en"},{"subitem_subject":"humidity","subitem_subject_language":"en"},{"subitem_subject":"durometer","subitem_subject_language":"en"},{"subitem_subject":"softening","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"ニフェジピンソフトカプセルは湿度の影響により 二相性の軟化を示す","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ニフェジピンソフトカプセルは湿度の影響により 二相性の軟化を示す","subitem_title_language":"ja"}]},"item_type_id":"10002","owner":"18","path":["29","1695351854159"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-09-30"},"publish_date":"2023-09-30","publish_status":"0","recid":"2000050","relation_version_is_last":true,"title":["ニフェジピンソフトカプセルは湿度の影響により 二相性の軟化を示す"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-09-12T09:00:10.976211+00:00"}