{"created":"2025-03-24T23:02:41.862560+00:00","id":2000204,"links":{},"metadata":{"_buckets":{"deposit":"6fc11505-64e9-47f3-9f6b-4da42abf68f9"},"_deposit":{"created_by":18,"id":"2000204","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000204"},"status":"published"},"_oai":{"id":"oai:hokuriku.repo.nii.ac.jp:02000204","sets":[]},"author_link":[],"control_number":"2000204","item_10002_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Toxic AGEs (TAGE) cause lifestyle-related diseases","subitem_alternative_title_language":"en"}]},"item_10002_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"58","bibliographicPageEnd":"320","bibliographicPageStart":"303","bibliographic_titles":[{"bibliographic_title":"北陸大学紀要","bibliographic_titleLang":"ja"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"筆者らは、生活習慣病（lifestyle-related diseases, LSRD）の発症・進展の新たな原因因子として、体内で生成・蓄積する毒性終末糖化産物（toxic advanced glycation end-products, toxicAGEs, TAGE と命名）を世界で初めて特定した。糖代謝中間体である三炭糖のglyceraldehydeから生成されるTAGE がLSRD と深く関連していることを明らかにし、“TAGE 原因説”という新たな概念を提唱している。血中TAGE 濃度の上昇はLSRD の発症・進展に関連していることが示唆されており、TAGE 濃度を測定することで将来の疾患の発症・進展を早期に予測できる可能性がある。また、最近の研究により、TAGE の分解経路や構造が明らかになっている。\n“TAGE 原因説”はLSRD の理解に斬新な知見をもたらすものであり、多くの疾患研究に新たな展望を開くものと期待される。本稿では、LSRD の発症・進展における「新規ターゲットTAGE」に関する研究の概要を紹介する。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_full_name_3":{"attribute_name":"著者（英）","attribute_value_mlt":[{"names":[{"name":"Takeuchi Masayoshi"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"北陸大学","subitem_publisher_language":"ja"}]},"item_10002_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本総説は、北陸大学創立50 周年記念として執筆したものである。〔査読あり〕の総説","subitem_rights_language":"ja"}]},"item_10002_source_id_9":{"attribute_name":"item_10002_source_id_9","attribute_value_mlt":[{"subitem_source_identifier":"2186-3989","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"元北陸大学薬学部教授・金沢医科大学総合医学研究所先端医療研究領域","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"竹内正義","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"20154982"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-04-06"}],"filename":"other01.pdf","filesize":[{"value":"3.3 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://hokuriku.repo.nii.ac.jp/record/2000204/files/other01.pdf"},"version_id":"3ed58dff-cfe5-42a2-973b-622a975fd8ea"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"生活習慣病におけるToxic AGEs (TAGE) 原因説","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生活習慣病におけるToxic AGEs (TAGE) 原因説","subitem_title_language":"ja"}]},"item_type_id":"10002","owner":"18","path":["1726131352099"],"pubdate":{"attribute_name":"公開日","attribute_value":"2025-03-25"},"publish_date":"2025-03-25","publish_status":"0","recid":"2000204","relation_version_is_last":true,"title":["生活習慣病におけるToxic AGEs (TAGE) 原因説"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2025-04-11T01:34:01.010637+00:00"}