{"created":"2023-06-19T08:25:35.040587+00:00","id":489,"links":{},"metadata":{"_buckets":{"deposit":"0987e123-f0b7-403d-9450-8d6461623d27"},"_deposit":{"created_by":18,"id":"489","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"489"},"status":"published"},"_oai":{"id":"oai:hokuriku.repo.nii.ac.jp:00000489","sets":["38:143"]},"author_link":["357","358","359"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"644","bibliographicPageStart":"638","bibliographicVolumeNumber":"54","bibliographic_titles":[{},{"bibliographic_title":"Journal of Health Science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"6-ヒドロキシドパミン(6-OHDA)は、パーキンソン病(PD)の病因に関連すると推定されるドパミン作動性神経毒である。ゲニピンが6-OHDA誘発性細胞毒性に対し保護作用を有するか否か検討した。6-OHDAは、濃度依存的にマウス神経芽細胞腫Neuro2a細胞の細胞生存を著しく低下させ、DNA凝縮、断片化をもたらしたが、ゲニピンは本神経毒性に対し有意に細胞を保護した。ゲニピンは、過酸化水素(H2O2)誘発性細胞毒性に対しても細胞保護を示した。6-OHDAは、分子酸素により迅速かつ非酵素的に酸化され、H2O2及び対応する-pキノンを形成することが知られている。以上より、ゲニピンはPD等の酸化ストレスが関与する神経変性に対し、効果的な保護作用を有することが示唆された。","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"公益社団法人日本薬学会"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-9702","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamazaki, Matsumi"}],"nameIdentifiers":[{"nameIdentifier":"357","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000020069787","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000020069787"}]},{"creatorNames":[{"creatorName":"Chiba, Kenzo"}],"nameIdentifiers":[{"nameIdentifier":"358","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000020069807","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000020069807"}]},{"creatorNames":[{"creatorName":"Satoh, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"359","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-12"}],"displaytype":"detail","filename":"Journal of Health Science  2008.12.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Journal of Health Science  2008.12","url":"https://hokuriku.repo.nii.ac.jp/record/489/files/Journal of Health Science  2008.12.pdf"},"version_id":"f2289278-602d-4975-ae15-66f5fa4274e4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"6-hydroxydopamine, hydrogen peroxide, genipin, neuroprotection, Neuro2a cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neuro2a Cell Death induced by 6-Hydroxydopamine is Attenuated by Genipin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neuro2a Cell Death induced by 6-Hydroxydopamine is Attenuated by Genipin"},{"subitem_title":"Neuro2a Cell Death induced by 6-Hydroxydopamine is Attenuated by Genipin","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"18","path":["143"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-12"},"publish_date":"2017-09-12","publish_status":"0","recid":"489","relation_version_is_last":true,"title":["Neuro2a Cell Death induced by 6-Hydroxydopamine is Attenuated by Genipin"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T08:35:14.025262+00:00"}