{"created":"2023-06-19T08:25:35.340927+00:00","id":494,"links":{},"metadata":{"_buckets":{"deposit":"70c04d27-d143-410b-8dfc-870e335e09e9"},"_deposit":{"created_by":18,"id":"494","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"494"},"status":"published"},"_oai":{"id":"oai:hokuriku.repo.nii.ac.jp:00000494","sets":["38:143"]},"author_link":["357","358"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"773","bibliographicPageStart":"769","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":" Journal of Health Science"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"神経性の一酸化窒素シンターゼ(NOS)がPC12h細胞中で、神経突起生成に関する機能的役割を果たすか否かを検討した。L-リジンとL-ノルバリンはNOSと同じ基質を使用するアルギナーゼの阻害薬であり、PC12h細胞中では著しい神経突起生成を誘導するが、PC12細胞中ではこの作用は認められなかった。PC12h細胞中では、L-リジンが誘導する神経突起生成は、非選択的NOS阻害薬であるNG-ニトロ-L-アルギニンメチルエステル(L-NAME)によって完全に阻害されたが、その異性体であるD-NAMEでは阻害されなかった。これらの結果から、基質の細胞内増加に伴って起こるアルギナーゼ阻害薬によるNOS活性のアップレギュレーションは、NOS発現細胞の神経突起生成を誘導すると思われた。以上より、発現した神経性NOSはPC12h細胞中で神経突起生成に対する機能的役割を果たすと思われた。","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"公益社団法人日本薬学会"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-9702","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamazaki, Matsumi"}],"nameIdentifiers":[{"nameIdentifier":"357","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000020069787","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000020069787"}]},{"creatorNames":[{"creatorName":"Chiba, Kenzo"}],"nameIdentifiers":[{"nameIdentifier":"358","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000020069807","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000020069807"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-16"}],"displaytype":"detail","filename":"Journal of Health Science  2006.12.pdf","filesize":[{"value":"339.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Journal of Health Science  2006.12","url":"https://hokuriku.repo.nii.ac.jp/record/494/files/Journal of Health Science  2006.12.pdf"},"version_id":"7be1abd0-43a8-42f1-bf49-b2ef22b23df0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"nitric oxide synthase, arginase, neurite outgrowth, genipin, PC12h cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of Functional Nitric Oxide Synthase for Neuritogenesis in PC12h Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of Functional Nitric Oxide Synthase for Neuritogenesis in PC12h Cells"},{"subitem_title":"Expression of Functional Nitric Oxide Synthase for Neuritogenesis in PC12h Cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"18","path":["143"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-01-16"},"publish_date":"2018-01-16","publish_status":"0","recid":"494","relation_version_is_last":true,"title":["Expression of Functional Nitric Oxide Synthase for Neuritogenesis in PC12h Cells"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T08:35:11.291294+00:00"}