{"created":"2023-06-19T08:25:35.407904+00:00","id":495,"links":{},"metadata":{"_buckets":{"deposit":"2478fd5c-1a92-4172-99bb-e5e7b14659f1"},"_deposit":{"created_by":18,"id":"495","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"495"},"status":"published"},"_oai":{"id":"oai:hokuriku.repo.nii.ac.jp:00000495","sets":["38:143"]},"author_link":["357","358"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"692","bibliographicPageStart":"687","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":" Journal of Health Science"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マウス神経芽細胞腫Neuro2a細胞中におけるゲニピンの神経分化誘導効果を検討した.ゲニピンは血清無添加・トランスフェリン/インスリン/プロゲステロン(TIP)添加培地で培養されたNeuro2a細胞中で,著しい神経突起伸長を濃度依存的に誘起した.この培地中では細胞増殖が抑制されたが,血清含有培地ではNeuro2a細胞の分裂が起きた.血清・TIP無添加培地は血清無添加・TIP添加培地に比べてトリパンブルーで染色される細胞数が明らかに増加していた.血清・TIP無添加培地にゲニピンを添加すると,細胞への障害は著しく減少した.神経分化誘導作用の陽性対照であるジブチリルcAMPも血清無添加・TIP添加培地中で神経突起伸長促進活性を誘起し,血清・TIP無添加培地中で培養細胞の生存率を促進した.以上より,ゲニピンはNeuro2a細胞中で血清欠乏性が誘起する神経分化誘導効果と残存効果を持つと思われた","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"公益財団法人日本薬学会"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-9702","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamazaki, Matsumi"}],"nameIdentifiers":[{"nameIdentifier":"357","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000020069787","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000020069787"}]},{"creatorNames":[{"creatorName":"Chiba, Kenzo"}],"nameIdentifiers":[{"nameIdentifier":"358","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000020069807","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000020069807"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-16"}],"displaytype":"detail","filename":"Journal of Health Science  2005.12(2).pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Journal of Health Science  2005.12(2)","url":"https://hokuriku.repo.nii.ac.jp/record/495/files/Journal of Health Science  2005.12(2).pdf"},"version_id":"8eee4358-6323-4d42-a14f-c6d511b59fa8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"genipin, neurite outgrowth, survival, Neuro2a cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neurotrophic Effects of Genipin on Neuro2a Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neurotrophic Effects of Genipin on Neuro2a Cells"},{"subitem_title":"Neurotrophic Effects of Genipin on Neuro2a Cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"18","path":["143"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-01-16"},"publish_date":"2018-01-16","publish_status":"0","recid":"495","relation_version_is_last":true,"title":["Neurotrophic Effects of Genipin on Neuro2a Cells"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T08:35:14.677941+00:00"}