{"created":"2023-06-19T08:25:37.380956+00:00","id":536,"links":{},"metadata":{"_buckets":{"deposit":"414d18ef-14ae-49cb-9c47-87d37158fb60"},"_deposit":{"created_by":18,"id":"536","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"536"},"status":"published"},"_oai":{"id":"oai:hokuriku.repo.nii.ac.jp:00000536","sets":["38:142"]},"author_link":["482","477","369","485","488","480","479","483","481","478","307","486","487","484"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1409","bibliographicPageStart":"1403","bibliographicVolumeNumber":"31","bibliographic_titles":[{},{"bibliographic_title":"Biological & Pharmaceutical Bulletin ","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We assessed the effects of different classes of flavonoids on insulin-stimulated 2-deoxy-D-[1-3H]glucose uptake by mouse MC3T3-G2/PA6 cells differentiated into mature adipose cells. Among the flavonoids examined, the flavones, apigenin and luteolin, the flavonols, kaempferol, quercetin and fisetin, an isoflavone, genistein, a flavanonol, silybin, and the flavanols, (−)-epigallocatechin gallate (EGCG) and theaflavins, significantly inhibited insulin-stimulated glucose uptake. Key structural features of flavonoids for inhibition of insulin-stimulated glucose uptake are the B-ring 4′- or 3′,4′-OH group and the C-ring C2–C3 double bond of the flavones and flavonols, the A-ring 5-OH of isoflavones, and the galloyl group of EGCG and theaflavins. Luteolin significantly inhibits insulin-stimulated phosphorylation of insulin receptor-β subunit (IR-β), and apigenin, kaempferol, quercetin and fisetin, also tended to inhibit the IR-β phosphorylation. On the other hand, isoflavones, flavanols or flavanonols did not affect insulin-stimulated IR-β phosphorylation. Apigenin, luteolin, kaempferol, quercetin and fisetin also appeared to inhibit insulin-stimulated activation of Akt, a pivotal downstream effector of phosphatidylinositol 3-kinase (PI3K), and suppressed insulin-dependent translocation of a glucose transporter, (GLUT)4, into the plasma membrane. Although genistein, silybin, EGCG and theaflavins had no effect on the insulin-stimulated activation of Akt, they blocked insulin-dependent GLUT4 translocation. These results provide novel insights into the modulation by flavonoids of insulin's actions, including glucose uptake in adipocytes. ","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"公益社団法人日本薬学会"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nomura , Masaaki"},{"creatorName":"Nomura , Masaaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000345286515","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000345286515"},{"nameIdentifier":"20247480 ","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"20247480 ","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20247480 "}]},{"creatorNames":[{"creatorName":"Takahashi, Tatsuo"},{"creatorName":"Takahashi, Tatsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"307","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000345286515","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000345286515"},{"nameIdentifier":"1000050445904","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"50445904","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50445904"}]},{"creatorNames":[{"creatorName":"Nagata , Naoto"}],"nameIdentifiers":[{"nameIdentifier":"478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsutsumi , Kikue"}],"nameIdentifiers":[{"nameIdentifier":"479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Shinjiro"},{"creatorName":"Kobayashi, Shinjiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"369","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000010186744","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000010186744"},{"nameIdentifier":"10186744 ","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10186744 "}]},{"creatorNames":[{"creatorName":"Akiba , Tetsuo"}],"nameIdentifiers":[{"nameIdentifier":"480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokogawa , Koichi"}],"nameIdentifiers":[{"nameIdentifier":"481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moritani , Shuzo"}],"nameIdentifiers":[{"nameIdentifier":"482","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyamoto , Ken-ichi"},{"creatorName":"Miyamoto , Ken-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"483","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30100514 ","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30100514 "}]},{"creatorNames":[{"creatorName":"Nagata , Naoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsutsumi , Kikue","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"485","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akiba, Tetsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokogawa , Koichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"487","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moritani , Shuzo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-18"}],"displaytype":"detail","filename":"Biological & Pharmaceutical Bulletin 2008.07.pdf","filesize":[{"value":"791.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Biological & Pharmaceutical Bulletin 2008.07","url":"https://hokuriku.repo.nii.ac.jp/record/536/files/Biological & Pharmaceutical Bulletin 2008.07.pdf"},"version_id":"fc2b13d3-b1e3-42be-a6ac-29fdc60e4644"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"flavonoid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adipocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glucose uptake","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Akt","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glucose transporter 4","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibitory Mechanisms of Flavonoids on Insulin-Stimulated Glucose Uptake in MC3T3-G2/PA6 Adipose Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibitory Mechanisms of Flavonoids on Insulin-Stimulated Glucose Uptake in MC3T3-G2/PA6 Adipose Cells"},{"subitem_title":"Inhibitory Mechanisms of Flavonoids on Insulin-Stimulated Glucose Uptake in MC3T3-G2/PA6 Adipose Cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"18","path":["142"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-18"},"publish_date":"2018-07-18","publish_status":"0","recid":"536","relation_version_is_last":true,"title":["Inhibitory Mechanisms of Flavonoids on Insulin-Stimulated Glucose Uptake in MC3T3-G2/PA6 Adipose Cells"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T08:34:14.837127+00:00"}