{"created":"2023-06-19T08:25:37.521294+00:00","id":538,"links":{},"metadata":{"_buckets":{"deposit":"c114ac1a-e0cd-4675-9bd7-a9674adb2d8c"},"_deposit":{"created_by":18,"id":"538","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"538"},"status":"published"},"_oai":{"id":"oai:hokuriku.repo.nii.ac.jp:00000538","sets":["38:142"]},"author_link":["494","491","493","496","498","495","492","497"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1394","bibliographicPageStart":"1390","bibliographicVolumeNumber":"30","bibliographic_titles":[{},{"bibliographic_title":"Biological & Pharmaceutical Bulletin ","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Previously, we have reported that the exposure of PC12 cells to the aluminum–maltolate complex (Al(maltol)3) results in decreased cell viability via the apoptotic cell death pathway. In this study, we have used several nitric oxide synthase (NOS) inhibitors and the NO generator diethylenetriamine NONOate (DETA NONOate) to examine whether or not intracellular nitric oxide (NO) generation is involved in the onset mechanism of Al(maltol)3-induced cell death. Cell viability was assessed by measuring lactate dehydrogenase (LDH) release and caspase-3 activity. Treatment of the cells with 150 μM Al(maltol)3 for 48 h resulted in intracellular NO generation. Exposure of the cells to DETA NONOate also induced a marked decrease in cell viability. Pre-treatment of the cells with a general NOS inhibitor or with a selective inducible NOS (iNOS) inhibitor effectively prevented Al(maltol)3-induced cell death. However, a neuronal NOS (nNOS) inhibitor did not exhibit any protective effect against Al(maltol)3-induced cell death. In addition, ascorbic acid markedly inhibited Al(maltol)3- and DETA NONOate-induced cell death. Based on these results, we discussed the involvement of intracellular NO generation in the onset mechanisms of Al(maltol)3-induced cell death. ","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"公益社団法人日本薬学会"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Satoh, Eiko "},{"creatorName":"Satoh, Eiko ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20298368 ","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20298368 "}]},{"creatorNames":[{"creatorName":"Yasuda , Iho"}],"nameIdentifiers":[{"nameIdentifier":"492","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada , Tomoko"}],"nameIdentifiers":[{"nameIdentifier":"493","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki , Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"494","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohyashiki , Takao"},{"creatorName":"Ohyashiki , Takao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"495","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00100488 ","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00100488 "}]},{"creatorNames":[{"creatorName":"Yasuda , Iho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada , Tomoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"497","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki , Yasuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"498","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-18"}],"displaytype":"detail","filename":"Biological & Pharmaceutical Bulletin 2007.08.pdf","filesize":[{"value":"399.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Biological & Pharmaceutical Bulletin 2007.08","url":"https://hokuriku.repo.nii.ac.jp/record/538/files/Biological & Pharmaceutical Bulletin 2007.08.pdf"},"version_id":"2663c153-3879-48e3-8fb2-2657fdc76f14"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"aluminum toxicity｜nitric oxide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"caspase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ascorbic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Involvement of NO Generation in Aluminum-Induced Cell Death","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Involvement of NO Generation in Aluminum-Induced Cell Death"},{"subitem_title":"Involvement of NO Generation in Aluminum-Induced Cell Death","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"18","path":["142"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-18"},"publish_date":"2018-07-18","publish_status":"0","recid":"538","relation_version_is_last":true,"title":["Involvement of NO Generation in Aluminum-Induced Cell Death"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T08:34:17.146421+00:00"}