@article{oai:hokuriku.repo.nii.ac.jp:00000687,
 author = {清水, 慶久 and Shimizu, Yoshihisa and 右田 , 平八 and Migita , Heihachi and 砂子澤　, 裕 and Isakozawa , Yutaka},
 issue = {52},
 journal = {北陸大学紀要, Bulletin of Hokuriku University},
 month = {Mar},
 note = {Background: Olfactory sensation is closely linked to the autonomic nervous system. In recent
years, stimulation of olfactory sensation through aroma therapy is widely used for prevention
of dementia and alleviation of physical/mental strain in the medical care. However, the
efficacy of the aroma therapy has been evaluated subjectively with lack of well-defined
objective methodologies. In this study, focusing on the gender differences among young adults,
we evaluated physiological responses induced by focused exposure to a variety of aroma
scents.
Methods: Twelve healthy young adults (6 males, 6 females) were enrolled. By use of
stereotactic device, Aroma Shooter®, five typical scents were accurately shot intermittently.
Physiological responses were measured as (1) frequency characteristics of autonomic nerve
(high and low frequencies: HF, LF) by use of a cardiac monitor, and (2) regional saturation of
oxygen (rSO₂) at frontal cortex by use of cerebral oximeter monitoring system, INVOS-5100C,
attached to the forehead.
Results and Discussion: Although the scent of coffee has been reported to stimulate
sympathetic tone (LF/HF), our results showed that, in contrast to males, it rather stimulated
parasympathetic tone (HF) in females (P=0.009). Whereas, the scent of peppermint is
generally known to stimulate sympathetic tone. We confirmed it in males, but the effect was
weak in females (P=0.310). Similarly, in cypress, it acts on the sympathetic nerve in males,
but not in females. No change in the forehead rSO2 of the brain with respect to aroma was
detected, and its usefulness for determining the effect of each aroma was not recognized. 
However, the gender difference was clearly significantly higher in males. In addition, both
males and females tended to gradually decline over time, and the effect was greater for
females than for males.
Conclusion: Changes in autonomic nervous tone after exposure to aroma scents tend to differ
between-sexes from one aroma to another.},
 pages = {229--240},
 title = {アロマフレングランスの時系列変化が自律神経に与える影響 －若年層男女における反応性の比較－},
 year = {2022},
 yomi = {シミズ, ヨシヒサ and ミギタ, ヘイハチ and イサコザワ, ユタカ}
}