{"created":"2023-06-19T08:25:45.973579+00:00","id":705,"links":{},"metadata":{"_buckets":{"deposit":"3336c153-56b1-4936-98ef-72ecfcea9459"},"_deposit":{"created_by":18,"id":"705","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"705"},"status":"published"},"_oai":{"id":"oai:hokuriku.repo.nii.ac.jp:00000705","sets":["29:171"]},"author_link":["749","736","737","750","747","500","558","748"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-09-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"53","bibliographicPageEnd":"56","bibliographicPageStart":"39","bibliographic_titles":[{"bibliographic_title":"北陸大学紀要"},{"bibliographic_title":"Bulletin of Hokuriku University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"グルカゴン様ペプチド-1（GLP-1）受容体作動薬は血糖依存性にインスリン分泌を促し、\n低血糖を生じにくい糖尿病治療薬であるが、強い消化器症状の副作用を伴うため高齢 2 型\n糖尿病患者に対する十分な検証がなされていない。そこで我々は GLP-1 受容体作動薬デ\nュラグルチドを用いて高齢 2 型糖尿病患者に対する有効性と安全性および QOL への影響\nについて探索的研究を実施した。\nデザインは同時対象のない非盲検前向き介入試験とした。地域医療機能推進機構金沢病\n院の高齢 2 型糖尿病患者 9 名の持効型インスリン製剤をデュラグルチドへ切り替えた。切\nり替え日より血糖値、HbA1c そして QOL を測定した。切り替え後、1 日の平均値血糖値\nは変化しなかったが、1 日の血糖値の標準偏差は有意に縮小した。また、持効型インスリ\nン製剤で観察された夜間低血糖はデュラグルチドへの切り替えにより解消した。さらに、\n中長期的な HbA1c の変化はなかったが、満足度、利便性、融通性に関する QOL が上昇し\nた。このことから、デュラグルチドは高齢 2 型糖尿病患者の血糖の質の改善と QOL 向上\nをもたらすことが明らかになった。しかし、糖尿病歴が長く、合併症の三兆候を有する高\n齢2型糖尿病患者3名が悪心嘔吐の副作用によって試験中止となった。今後、同様の症例\nに対してデュラグルチドを投与する際は消化器症状の慎重なモニタリングが必要である。","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"　　　　　　　　　　　　　　　　　","subitem_description_type":"Other"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15066/00000660","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"北陸大学"}]},"item_10002_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"〔査読有り〕の原著論文　責任著者：岡田 守弘"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2186-3989","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 守弘"},{"creatorName":"オカダ, モリヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大橋 , 彩乃"},{"creatorName":"オオハシ, アヤノ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田 , 昌江"},{"creatorName":"オカダ, マサエ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"736","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西上 , 潤"},{"creatorName":"ニシカミ, ジュン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"737","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada , Morihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohashi, Ayano","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Masae ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"747","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishikami , Jun ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"748","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-22"}],"displaytype":"detail","filename":"yaku03.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yaku03","url":"https://hokuriku.repo.nii.ac.jp/record/705/files/yaku03.pdf"},"version_id":"9702a695-6312-4b9d-ae20-406e0c38fb68"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"高齢2型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"デュラグルチド","subitem_subject_scheme":"Other"},{"subitem_subject":"QOL","subitem_subject_scheme":"Other"},{"subitem_subject":"CGM","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DTSQ","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"高齢2型糖尿病患者を対象としたデュラグルチドの有効性と安全性およびQOLの検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高齢2型糖尿病患者を対象としたデュラグルチドの有効性と安全性およびQOLの検討"},{"subitem_title":"Examination of efficacy, safety, and quality of life of dulaglutide in elderly type 2 diabetic patients","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["171"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-09-30"},"publish_date":"2022-09-30","publish_status":"0","recid":"705","relation_version_is_last":true,"title":["高齢2型糖尿病患者を対象としたデュラグルチドの有効性と安全性およびQOLの検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T08:30:09.803642+00:00"}