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生活習慣病におけるTAGE(Toxic AGEs)病因説
https://doi.org/10.15066/00000185
https://doi.org/10.15066/00000185f4e0c5ce-f956-4cc5-8277-f7ef6dd39b2c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yaku3 (642.1 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-08-08 | |||||
| タイトル | ||||||
| タイトル | 生活習慣病におけるTAGE(Toxic AGEs)病因説 | |||||
| タイトル | ||||||
| タイトル | TAGE (toxic AGEs) hypothesis in life style-related disease | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | アルコール症(病因) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 黒色腫(病因) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 認知症(病因) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 糖尿病性神経障害(病因) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 糖尿病性腎症(病因) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 糖尿病網膜症(病因) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Advanced Glycosylation End Products(毒性・副作用) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | *生活習慣病(病因) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 糖代謝 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.15066/00000185 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
竹内, 正義
× 竹内, 正義 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The advanced stage of the glycation process (one of the post-translational modifications of proteins) leads to the formation of advanced glycation end-products (AGEs) and plays an important role in the pathogenesis of angiopathy in diabetic patients, in aging, and in neurodegenerative diseases. However, it is still not clear which AGEs subtypes play a pathogenetic role and which of several AGEs receptor mediate AGEs effects on cells. We have provided direct immunochemical evidence for the existence of six distinct AGEs structures (AGEs-1 to -6) within the AGEs-modified proteins and peptides that circulate in the serum of diabetic patients. Recently we demonstrated for the first time that glyceraldehyde-derived AGEs (AGE-2) and glycolaldehyde-derived AGEs (AGE-3) have diverse biological activities on vascular wall cells, mesangial cells, Schwann cells, malignant melanoma cells and cortical neurons. We also demonstrated for the first time that acetaldehyde (AA)-derived AGEs (AA-AGE) have cytotoxic activity on cortical neurons and the AA-AGE epitope was detected in human brain of alcoholics. These results indicate that of the various types of AGEs structures that can form in vivo, the toxic AGEs (TAGE) structures (AGEs-2, -3, and AA-AGE), but not non-toxic AGEs (N-carboxymethyllysine, pentosidine, pyrraline etc.) are likely to play an important role in the pathophysiological processes associated with AGEs formation. |
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| 書誌情報 |
北陸大学紀要 en : Bulletin of Hokuriku University 号 28, p. 33-48, 発行日 2004-12-31 |
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| 出版者 | ||||||
| 出版者 | 北陸大学 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0387-074X | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jamas.or.jp/user/database/Search/detail/scode/J00258 | |||||
| 関連名称 | 竹内正義著「生活習慣病の発症・進展におけるToxic AGEs(TAGE)-RAGE系の関与 新たな治療戦略」 金沢医科大学雑誌 (0385-5759)37巻4号 Page141-161(2012.12) | |||||
| 他の資源との関係 | ||||||
| 関連名称 | 第15回高岡市民文化賞（平成16年3月受賞）記念原稿 | |||||
