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  1. 学術雑誌
  2. Biological & Pharmaceutical Bulletin

A Protein Kinase C Inhibitor NA-382 Prolongs the Life Span of AH66F-Bearing Rats as Well as Inhibiting Leukocyte Function-Associated Antigen-1 (LFA-1)-Dependent Adhesion of the Cells

https://hokuriku.repo.nii.ac.jp/records/537
https://hokuriku.repo.nii.ac.jp/records/537
5205a0f0-3bfc-4c70-b351-e7c34bff2377
名前 / ファイル ライセンス アクション
Biological Biological & Pharmaceutical Bulletin 1996.12 (603.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-07-18
タイトル
タイトル A Protein Kinase C Inhibitor NA-382 Prolongs the Life Span of AH66F-Bearing Rats as Well as Inhibiting Leukocyte Function-Associated Antigen-1 (LFA-1)-Dependent Adhesion of the Cells
タイトル
タイトル A Protein Kinase C Inhibitor NA-382 Prolongs the Life Span of AH66F-Bearing Rats as Well as Inhibiting Leukocyte Function-Associated Antigen-1 (LFA-1)-Dependent Adhesion of the Cells
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 rat ascites hepatoma
キーワード
言語 en
主題Scheme Other
主題 AH66F
キーワード
言語 en
主題Scheme Other
主題 adhesion
キーワード
言語 en
主題Scheme Other
主題 LFA-1
キーワード
言語 en
主題Scheme Other
主題 protein kinase C
キーワード
言語 en
主題Scheme Other
主題 NA-382
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Nomura , Masaaki

× Nomura , Masaaki

WEKO 477
CiNii ID 9000345286515
NRID 20247480
e-Rad 20247480

Nomura , Masaaki

en Nomura , Masaaki

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Sugiura , Norihiko

× Sugiura , Norihiko

WEKO 489

Sugiura , Norihiko

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Miyamoto , Ken-ichi

× Miyamoto , Ken-ichi

WEKO 483
e-Rad 30100514

Miyamoto , Ken-ichi

en Miyamoto , Ken-ichi

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Sugiura , Norihiko

× Sugiura , Norihiko

WEKO 490

en Sugiura , Norihiko

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抄録
内容記述タイプ Abstract
内容記述 Rat ascites hepatoma AH66F is a high malignant tumor line, and AH66F-bearing rats died about 10 d after tumor inoculation. When treated with a protein kinase C (PKC) inhibitor, NA-382, the life span of AH66F-bearing rats was significantly prolonged, while a potent protein kinase A inhibitor, H-89, was not effective. In the adhesion assay, the adhesive ability to the mesentery-derived mesothelial cells (M-cells) of AH66F cells from rats injected with 10 mg/kg of NA-382 was significantly decreased, while the adhesion rate of the cells from the vehicle control group and from the H-89 (10 mg/kg)-treated group was about 50%. The adhesion of AH66F cells from the vehicle control group was curtailed to one half by leukocyte function-associated antigen-1 (LFA-1) β-chain monoclonal antibody (WT.3), but that from the NA-382 group was not further influenced by WT.3. In flow cytometric analysis using WT.3, the expression of LFA-1 β-chain on AH66F cells from the NA-382-treated group was also partially decreased, while that from the H-89-treated group was not changed. It was confirmed in vitro that after treatment with these protein kinase inhibitors for 48 h the expression of LFA-1 β-chain in the cells was decreased by NA-382, but not by H-89. These results suggested that the PKC inhibitor prolongs the life span of AH66F-bearing rats through inhibition of LFA-1-dependent adhesion of the cells.
書誌情報 en : Biological & Pharmaceutical Bulletin

巻 19, 号 12, p. 1611-1613, 発行日 1996-12
出版者
出版者 公益社団法人日本薬学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 0918-6158
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