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A Protein Kinase C Inhibitor NA-382 Prolongs the Life Span of AH66F-Bearing Rats as Well as Inhibiting Leukocyte Function-Associated Antigen-1 (LFA-1)-Dependent Adhesion of the Cells
https://hokuriku.repo.nii.ac.jp/records/537
https://hokuriku.repo.nii.ac.jp/records/5375205a0f0-3bfc-4c70-b351-e7c34bff2377
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Biological & Pharmaceutical Bulletin 1996.12 (603.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2018-07-18 | |||||||||
| タイトル | ||||||||||
| タイトル | A Protein Kinase C Inhibitor NA-382 Prolongs the Life Span of AH66F-Bearing Rats as Well as Inhibiting Leukocyte Function-Associated Antigen-1 (LFA-1)-Dependent Adhesion of the Cells | |||||||||
| タイトル | ||||||||||
| タイトル | A Protein Kinase C Inhibitor NA-382 Prolongs the Life Span of AH66F-Bearing Rats as Well as Inhibiting Leukocyte Function-Associated Antigen-1 (LFA-1)-Dependent Adhesion of the Cells | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | rat ascites hepatoma | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | AH66F | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | adhesion | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | LFA-1 | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | protein kinase C | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | NA-382 | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Nomura , Masaaki
× Nomura , Masaaki
WEKO
477
× Sugiura , Norihiko× Miyamoto , Ken-ichi× Sugiura , Norihiko |
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Rat ascites hepatoma AH66F is a high malignant tumor line, and AH66F-bearing rats died about 10 d after tumor inoculation. When treated with a protein kinase C (PKC) inhibitor, NA-382, the life span of AH66F-bearing rats was significantly prolonged, while a potent protein kinase A inhibitor, H-89, was not effective. In the adhesion assay, the adhesive ability to the mesentery-derived mesothelial cells (M-cells) of AH66F cells from rats injected with 10 mg/kg of NA-382 was significantly decreased, while the adhesion rate of the cells from the vehicle control group and from the H-89 (10 mg/kg)-treated group was about 50%. The adhesion of AH66F cells from the vehicle control group was curtailed to one half by leukocyte function-associated antigen-1 (LFA-1) β-chain monoclonal antibody (WT.3), but that from the NA-382 group was not further influenced by WT.3. In flow cytometric analysis using WT.3, the expression of LFA-1 β-chain on AH66F cells from the NA-382-treated group was also partially decreased, while that from the H-89-treated group was not changed. It was confirmed in vitro that after treatment with these protein kinase inhibitors for 48 h the expression of LFA-1 β-chain in the cells was decreased by NA-382, but not by H-89. These results suggested that the PKC inhibitor prolongs the life span of AH66F-bearing rats through inhibition of LFA-1-dependent adhesion of the cells. | |||||||||
| 書誌情報 |
en : Biological & Pharmaceutical Bulletin 巻 19, 号 12, p. 1611-1613, 発行日 1996-12 |
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| 出版者 | ||||||||||
| 出版者 | 公益社団法人日本薬学会 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0918-6158 | |||||||||
