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Involvement of NO Generation in Aluminum-Induced Cell Death
https://hokuriku.repo.nii.ac.jp/records/538
https://hokuriku.repo.nii.ac.jp/records/5385beed3fb-5674-4a31-b118-55ea280481b4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Biological & Pharmaceutical Bulletin 2007.08 (399.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-07-18 | |||||
| タイトル | ||||||
| タイトル | Involvement of NO Generation in Aluminum-Induced Cell Death | |||||
| タイトル | ||||||
| タイトル | Involvement of NO Generation in Aluminum-Induced Cell Death | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | aluminum toxicity｜nitric oxide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | caspase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | ascorbic acid | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Satoh, Eiko
× Satoh, Eiko× Yasuda , Iho× Yamada , Tomoko× Suzuki , Yasuyuki× Ohyashiki , Takao× Yasuda , Iho× Yamada , Tomoko× Suzuki , Yasuyuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Previously, we have reported that the exposure of PC12 cells to the aluminum–maltolate complex (Al(maltol)3) results in decreased cell viability via the apoptotic cell death pathway. In this study, we have used several nitric oxide synthase (NOS) inhibitors and the NO generator diethylenetriamine NONOate (DETA NONOate) to examine whether or not intracellular nitric oxide (NO) generation is involved in the onset mechanism of Al(maltol)3-induced cell death. Cell viability was assessed by measuring lactate dehydrogenase (LDH) release and caspase-3 activity. Treatment of the cells with 150 μM Al(maltol)3 for 48 h resulted in intracellular NO generation. Exposure of the cells to DETA NONOate also induced a marked decrease in cell viability. Pre-treatment of the cells with a general NOS inhibitor or with a selective inducible NOS (iNOS) inhibitor effectively prevented Al(maltol)3-induced cell death. However, a neuronal NOS (nNOS) inhibitor did not exhibit any protective effect against Al(maltol)3-induced cell death. In addition, ascorbic acid markedly inhibited Al(maltol)3- and DETA NONOate-induced cell death. Based on these results, we discussed the involvement of intracellular NO generation in the onset mechanisms of Al(maltol)3-induced cell death. | |||||
| 書誌情報 |
en : Biological & Pharmaceutical Bulletin 巻 30, 号 8, p. 1390-1394, 発行日 2007-08 |
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| 出版者 | ||||||
| 出版者 | 公益社団法人日本薬学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0918-6158 | |||||
